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Nature Strucural & Molecular Biology
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
Sat, 02/04/2012 - 03:00A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
Nature Structural & Molecular Biology 19, 264 (2012). doi:10.1038/nsmb0212-264
Author: Anne-Catrin Uhlemann, Angus Cameron, Ursula Eckstein-Ludwig, Jorge Fischbarg, Pavel Iserovich, Felipe A Zuniga, Malcolm East, Anthony Lee, Leo Brady, Richard K Haynes & Sanjeev Krishna
Categories: Journals
It takes two to transport, or is it one?
Fri, 02/03/2012 - 00:00It takes two to transport, or is it one?
Nature Structural & Molecular Biology 19, 129 (2012). doi:10.1038/nsmb.2239
Authors: Hyun-Ho Lim & Christopher Miller
The proteins that 'pump' neurotransmitters into neurons, clearing the synapse after a nerve impulse, are central players in coherent brain function and are targets of many psychotropic drugs. Two groups now endeavor to resolve a fundamental controversy about how these proteins work. The results shed new light on the controversy but do not end it.
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Cbl exposes its RING finger
Fri, 02/03/2012 - 00:00Cbl exposes its RING finger
Nature Structural & Molecular Biology 19, 131 (2012). doi:10.1038/nsmb.2241
Authors: Stephen C Kales, Philip E Ryan & Stanley Lipkowitz
The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restricted to specific substrates.
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A team effort blocks the ribosome in its tracks
Fri, 02/03/2012 - 00:00A team effort blocks the ribosome in its tracks
Nature Structural & Molecular Biology 19, 133 (2012). doi:10.1038/nsmb.2236
Author: Amy E Pasquinelli
A complex of PUF (named after founding members Pumilio and Fem-3 binding factor) and Argonaute proteins can stall translation elongation on bound mRNAs by interacting with eEF1A and inhibiting its GTPase activity.
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Swift, strandwise translocation
Fri, 02/03/2012 - 00:00Swift, strandwise translocation
Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2249
Author: Angela K. Eggleston
Categories: Journals
Adaptation by RNA editing
Fri, 02/03/2012 - 00:00Adaptation by RNA editing
Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2246
Author: Arianne Heinrichs
Categories: Journals
Tumor-suppressive Smurf
Fri, 02/03/2012 - 00:00Tumor-suppressive Smurf
Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2248
Author: Steve Mason
Categories: Journals
Intrinsic regulation
Fri, 02/03/2012 - 00:00Intrinsic regulation
Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2247
Author: Michelle Montoya
Categories: Journals
Regulation of Rev1 by the Fanconi anemia core complex
Sun, 01/22/2012 - 00:00Regulation of Rev1 by the Fanconi anemia core complex
Nature Structural & Molecular Biology 19, 164 (2012). doi:10.1038/nsmb.2222
Authors: Hyungjin Kim, Kailin Yang, Donniphat Dejsuphong & Alan D D'Andrea
Categories: Journals
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
Sun, 01/22/2012 - 00:00Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
Nature Structural & Molecular Biology 19, 184 (2012). doi:10.1038/nsmb.2231
Authors: Hao Dou, Lori Buetow, Andreas Hock, Gary J Sibbet, Karen H Vousden & Danny T Huang
Categories: Journals
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
Sun, 01/22/2012 - 00:00The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
Nature Structural & Molecular Biology 19, 201 (2012). doi:10.1038/nsmb.2211
Authors: Lin Feng & Junjie Chen
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Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus
Sun, 01/22/2012 - 00:00Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus
Nature Structural & Molecular Biology 19, 238 (2012). doi:10.1038/nsmb.2213
Authors: Yushi Matsumoto, Takehiko Tosha, Andrei V Pisliakov, Tomoya Hino, Hiroshi Sugimoto, Shingo Nagano, Yuji Sugita & Yoshitsugu Shiro
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HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
Sun, 01/22/2012 - 00:00HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
Nature Structural & Molecular Biology 19, 253 (2012). doi:10.1038/nsmb.2223
Authors: Kalyan Das, Sergio E Martinez, Joseph D Bauman & Eddy Arnold
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Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
Sun, 01/15/2012 - 00:00Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
Nature Structural & Molecular Biology 19, 152 (2012). doi:10.1038/nsmb.2210
Authors: Hélène Malet, Flavia Canellas, Justyna Sawa, Jun Yan, Konstantinos Thalassinos, Michael Ehrmann, Tim Clausen & Helen R Saibil
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Phosphorylation-dependent activity of the deubiquitinase DUBA
Sun, 01/15/2012 - 00:00Phosphorylation-dependent activity of the deubiquitinase DUBA
Nature Structural & Molecular Biology 19, 171 (2012). doi:10.1038/nsmb.2206
Authors: Oscar W Huang, Xiaolei Ma, JianPing Yin, Jeremy Flinders, Till Maurer, Nobuhiko Kayagaki, Qui Phung, Ivan Bosanac, David Arnott, Vishva M Dixit, Sarah G Hymowitz, Melissa A Starovasnik & Andrea G Cochran
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Experimental conditions can obscure the second high-affinity site in LeuT
Sun, 01/15/2012 - 00:00Experimental conditions can obscure the second high-affinity site in LeuT
Nature Structural & Molecular Biology 19, 207 (2012). doi:10.1038/nsmb.2197
Authors: Matthias Quick, Lei Shi, Britta Zehnpfennig, Harel Weinstein & Jonathan A Javitch
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Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context
Sun, 01/15/2012 - 00:00Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context
Nature Structural & Molecular Biology 19, 212 (2012). doi:10.1038/nsmb.2215
Authors: Hui Wang, Johannes Elferich & Eric Gouaux
Categories: Journals
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Sun, 01/15/2012 - 00:00The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Nature Structural & Molecular Biology 19, 220 (2012). doi:10.1038/nsmb.2207
Authors: Olga Anczuków, Avi Z Rosenberg, Martin Akerman, Shipra Das, Lixing Zhan, Rotem Karni, Senthil K Muthuswamy & Adrian R Krainer
Categories: Journals
Molecular basis for RNA polymerization by Qβ replicase
Sun, 01/15/2012 - 00:00Molecular basis for RNA polymerization by Qβ replicase
Nature Structural & Molecular Biology 19, 229 (2012). doi:10.1038/nsmb.2204
Authors: Daijiro Takeshita & Kozo Tomita
Categories: Journals
The N domain of Argonaute drives duplex unwinding during RISC assembly
Tue, 01/10/2012 - 00:00The N domain of Argonaute drives duplex unwinding during RISC assembly
Nature Structural & Molecular Biology 19, 145 (2012). doi:10.1038/nsmb.2232
Authors: Pieter Bas Kwak & Yukihide Tomari
Categories: Journals