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2006
DeGenst E, SilenceK, DecanniereK, ConrathK, LorisR, KinneJ, MuyldermansS, WynsL.  2006.  Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. 103(12):4586-4591. Abstract
2005
SaerensD, PellisM, LorisR, PardonE, DumoulinM, MatagneA, WynsL, MuyldermansS, ConrathK.  2005.  Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies. 352(3):597-607. Abstract
ConrathK, VinckeC, StijlemansB, SchymkowitzJ, DecanniereK, WynsL, MuyldermansS, LorisR.  2005.  Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH. 350(1):112-125. Abstract
DeGenst E, SilenceK, GhahroudiMA, DecanniereK, LorisR, KinneJ, WynsL, MuyldermansS.  2005.  Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires. 280(14):14114-14121. Abstract
DumoulinM, CanetD, LastAM, PardonE, ArcherDB, MuyldermansS, WynsL, MatagneA, RobinsonCV, RedfieldC, DobsonCM.  2005.  Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations. Nature. 346(3):773-788. Abstract
2004
DeGenst E, HandelbergF, VanMeirhaeghe A, VynckS, LorisR, WynsL, MuyldermansS.  2004.  Chemical basis for the affinity maturation of a camel single domain antibody. 279(51):53593-53601. Abstract
StijlemansB, ConrathK, Cortez-RetamozoV, VanXong H, WynsL, SenterP, RevetsH, DeBaetselier P, MuyldermansS, MagezS.  2004.  Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. 279(2):1256-1261. Abstract
2003
DumoulinM, LastAM, DesmyterA, DecanniereK, CanetD, LarssonG, SpencerA, ArcherDB, SasseJ, MuyldermansS, WynsL, RedfieldC, MatagneA, RobinsonCV, DobsonCM.  2003.  A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. 424(6950):783-788. Abstract
LorisR, MarianovskyI, LahJ, LaeremansT, Engelberg-KulkaH, GlaserG, MuyldermansS, WynsL.  2003.  Crystal structure of the intrinsically flexible addiction antidote MazE. 278(30):28252-28257. Abstract
2002
DesmyterA, SpinelliS, PayanF, LauwereysM, WynsL, MuyldermansS, CambillauC.  2002.  Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology. 277(26):23645-23650. Abstract
DumoulinM, ConrathK, VanMeirhaeghe A, MeersmanF, HeremansK, FrenkenLG, MuyldermansS, WynsL, MatagneA.  2002.  Single-domain antibody fragments with high conformational stability. 11(3):500-515. Abstract
2001
DecanniereK, TransueTR, DesmyterA, MaesD, MuyldermansS, WynsL.  2001.  Degenerate interfaces in antigen-antibody complexes. 313(3):473-478. Abstract
ConrathKE, LauwereysM, GalleniM, MatagneA, FrereJM, KinneJ, WynsL, MuyldermansS.  2001.  Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. 45(10):2807-2812. Abstract
DesmyterA, DecanniereK, MuyldermansS, WynsL.  2001.  Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody. 276(28):26285-26290. Abstract
MuyldermansS, CambillauC, WynsL.  2001.  Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains. 26(4):230-235. Abstract
ElsConrath K, LauwereysM, WynsL, MuyldermansS.  2001.  Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. 276(10):7346-7350. Abstract
2000
DecanniereK, MuyldermansS, WynsL.  2000.  Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?. 300(1):83-91. Abstract
NguyenVK, HamersR, WynsL, MuyldermansS.  2000.  Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire. 19(5):921-930. Abstract
1999
NguyenVK, HamersR, WynsL, MuyldermansS.  1999.  Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies. 36(8):515-524. Abstract
DecanniereK, DesmyterA, LauwereysM, GhahroudiMA, MuyldermansS, WynsL.  1999.  A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops. 7(4):361-370. Abstract
GuptaV, MuyldermansS, WynsL, SalunkeDM.  1999.  The crystal structure of recombinant rat pancreatic RNase A. 35(1):1-12. Abstract
1998
TransueTR, DeGenst E, GhahroudiMA, WynsL, MuyldermansS.  1998.  Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate. 32(4):515-522. Abstract
LauwereysM, ArbabiGhahroudi M, DesmyterA, KinneJ, HolzerW, DeGenst E, WynsL, MuyldermansS.  1998.  Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. 17(13):3512-3520. Abstract
1997
VuKB, GhahroudiMA, WynsL, MuyldermansS.  1997.  Comparison of llama VH sequences from conventional and heavy chain antibodies. 34(16-17):1121-1131. Abstract
ArbabiGhahroudi M, DesmyterA, WynsL, HamersR, MuyldermansS.  1997.  Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. 414(3):521-526. Abstract

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