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2008
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2008. Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.
Eur. Journ. Med. Chem.. 43(2):315-326. Abstract
2007
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2007. Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
Journal Biological Chemistry. 282(48):35269-35278. Abstract
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2007. Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.
Journal of Bacteriology. 189(21):7626-7633. Abstract
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2007. Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax.
BBA. 1774(11):1451-1461. Abstract
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2007. 1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.
Bioorg. & Med. Chem. Lett.. 17(9):2523-2526. Abstract
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2007. The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.
FEBS J. 274(9):2363-2375. Abstract
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2007. Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.
Abstract
2006
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2006. Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry.
Biochemistry. 45(30):9307-9318. Abstract
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2006. Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.
Journal Molecular Biology. 359(2):331-346. Abstract
2005
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2005. Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system.
Nanoletters. 5(11):2220-2224. Abstract
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2005. Substrate-assisted leaving group activation in enzyme-catalyzed N-glycosidic bond cleavage.
J. Biol. Chem. 280(15):14799-14802. Abstract
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2005. Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules.
J Control Release. 102(1):171-179. Abstract
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2005. Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules.
102(1):171-179. Abstract
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2005. Influence of the pi-pi interaction on the hydrogen bonding capacity of stacked DNA/RNA bases.
Nucleic Acids Research. 33(6):1779-1789. Abstract
2004
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2004. Leaving group activation by aromatic stacking: an alternative to general acid catalysis.
J. Mol. Biol. 338(1):1-6. Abstract
2003
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2003. Catalysis by nucleoside hydrolases.
Current opinion in structural biology. 13(6):731-738. Abstract
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2003. Pre-steady-state analysis of the nucleoside hydrolase of Trypanosoma vivax. Evidence for half-of-the-sites reactivity and rate-limiting product release.
Biochemistry. 42(44):12902-12908. Abstract
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2003. Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni.
Acta Crystallographica D. 59(Pt 6):1087-1089. Abstract
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2003. Ribonucleases: from prototypes to therapeutic targets?.
Current Medicinal Chemistry. 10(9):779-785. Abstract
2002
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2002. A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.
Journal Bioogical Chemistry. 277(39):36770-36774. Abstract
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2002. Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.
J. Biol. Chem. 277(18):15938-15946. Abstract
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2002. Enzyme-Substrate Interactions in the Purine-specific Nucleoside Hydrolase from Trypanosoma vivax.
J. Biol. Chem.. 277:15938-15946. Abstract
2001
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2001. Hydrophobic core manipulations in ribonuclease T1.
Biochemistry. 40(34):10140-10149. Abstract
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2001. The contribution of metal ions to the conformational stability of ribonuclease T1: crystal versus solution.
268(14):3993-4000. Abstract
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2001. Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
307(5):1363-1379. Abstract
