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2007
GoeminneA, McNaughtonM, BalG, SurpateanuG, VanDerV, DeProl S, VerseesW, SteyaertJ, ApersS, HaemersA, AugustynsK.  2007.  1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors. Bioorg. & Med. Chem. Lett.. 17(9):2523-2526. Abstract
2006
RoosG, BrosensE, WahniK, DesmyterA, SpinelliS, WynsL, MessensJ, LorisR.  2006.  Combining site-specific mutagenesis and seeding as a strategy to crystallize 'difficult' proteins: the case of Staphylococcus aureus thioredoxin. Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun.. 62(Pt 12):1255-1258. Abstract
VandemeulebrouckeA, VerseesW, SteyaertJ, BarlowJN.  2006.  Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry. Biochemistry. 45(30):9307-9318. Abstract
2005
WillaertR, ZegersI, WynsL, SleutelM.  2005.  Protein crystallization in hydrogel beads. 61(Pt 9):1280-1288. Abstract
ButsL, WellensA, Van MolleI, WynsL, LorisR, LahmannM, OscarsonS, De GreveH, BouckaertJ.  2005.  Impact of natural variation in bacterial F17G adhesins on crystallization behaviour. Acta Cryst. D. 61(Pt 8):1149-1159. Abstract
Van MolleI, ButsL, CoppensF, QiangL, WynsL, LorisR, BouckaertJ, De GreveH.  2005.  Crystallization of the FaeE chaperone of Escherichia coli F4 fimbriae. Acta Crystallographica Section F. 61(Pt 4):427-431. Abstract
VanWalleI, LastersI, WynsL.  2005.  SABmark--a benchmark for sequence alignment that covers the entire known fold space. 21(7):1267-1268. Abstract
HuysmansG, RanquinA, WynsL, SteyaertJ, VanGelder P.  2005.  Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules. J Control Release. 102(1):171-179. Abstract
HuysmansG, RanquinA, WynsL, SteyaertJ, VanGelder P.  2005.  Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules. 102(1):171-179. Abstract
2004
ParretAH, WynsL, DeMot R, LorisR.  2004.  Overexpression, purification and crystallization of bacteriocin LlpA from Pseudomonas sp. BW11M1. 60(Pt 10):1922-1924. Abstract
VanWalleI, LastersI, WynsL.  2004.  Align-m--a new algorithm for multiple alignment of highly divergent sequences. 20(9):1428-1435. Abstract
ButsL, Dao-ThiMH, WynsL, LorisR.  2004.  Untangle, a tool for filtering overlapping diffraction patterns from multicrystals. 60(Pt 5):983-984. Abstract
2003
VerseesW, SteyaertJ.  2003.  Catalysis by nucleoside hydrolases. Current opinion in structural biology. 13(6):731-738. Abstract
CanetD, LyonCE, ScheekRM, RobillardGT, DobsonCM, HorePJ, van NulandNA.  2003.  Rapid formation of non-native contacts during the folding of HPr revealed by real-time photo-CIDNP NMR and stopped-flow fluorescence experiments. 330(2):397-407. Abstract
LahJ, MarianovskyI, GlaserG, Engelberg-KulkaH, KinneJ, WynsL, LorisR.  2003.  Recognition of the intrinsically flexible addiction antidote MazE by a dromedary single domain antibody fragment. Structure, thermodynamics of binding, stability, and influence on interactions with DNA. 278(16):14101-14111. Abstract
HsuST, BreukinkE, BierbaumG, SahlHG, deKruijff B, KapteinR, van NulandNA, BonvinAM.  2003.  NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity. 278(15):13110-13117. Abstract
VanWalleI, LastersI, WynsL.  2003.  Consistency matrices: quantified structure alignments for sets of related proteins. 51(1):1-9. Abstract
2002
MignonP, SteyaertJ, LorisR, GeerlingsP, LoverixS.  2002.  A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study. Journal Bioogical Chemistry. 277(39):36770-36774. Abstract
HsuST, BreukinkE, deKruijff B, KapteinR, BonvinAM, van NulandNA.  2002.  Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles. 41(24):7670-7676. Abstract
VanWalleI, WynsL.  2002.  Multiple alignment of sequences and structures. 67(4):31-34.
1999
Huyghues-DespointesBM, LanghorstU, SteyaertJ, PaceCN, ScholtzJM.  1999.  Hydrogen-exchange stabilities of RNase T1 and variants with buried and solvent-exposed Ala --> Gly mutations in the helix. Biochemistry. 38(50):16481-16490. Abstract
1998
ZegersI, LorisR, DehollanderG, FattahHaikal A, PoortmansF, SteyaertJ, WynsL.  1998.  Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. 5(4):280-283. Abstract
ZegersI, LorisR, DehollanderG, FattahHaikal A, PoortmansF, SteyaertJ, WynsL.  1998.  Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. 5(4):280-283. Abstract
DeVos S, DoumenJ, LanghorstU, SteyaertJ.  1998.  Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position. 275(4):651-661. Abstract
1997
elBouyoussfi M, LausG, VerheydenP, WynsL, TourweD, VanBinst G.  1997.  Location of the three disulfide bonds in an antimicrobial peptide from Amaranthus caudatus using mass spectrometry. 49(4):336-340. Abstract