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1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors

Publication Type:

Journal Article

Authors:

Goeminne,A.; McNaughton,M.; Bal,G.; Surpateanu,G.; Van,Der,V; De,Prol S.; Versees,W.; Steyaert,J.; Apers,S.; Haemers,A.; Augustyns,K.

Source:

Bioorg. & Med. Chem. Lett., Volume 17, Issue 9, p.2523 - 2526 (2007)

URL:

PM:17317181

Keywords:

analogs & derivatives; Animals; antagonists & inhibitors; CHEMICAL SYNTHESIS; chemistry; Chemistry; Pharmaceutical; DERIVATIVES; Drug Design; Enzyme Inhibitors; enzymology; Kinetics; methods; Models; Chemical; Molecular Conformation; N-Glycosyl Hydrolases;

Abstract:

A range of novel 1,2,3-triazolylalkylribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase inhibitors, which, along with the simplicity of the chemistry involved in its synthesis, makes it a good lead for the further development of novel nucleoside hydrolase inhibitors

Notes:

DA - 20070406
IS - 0960-894X (Print)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Enzyme Inhibitors)
RN - 0 (Triazoles)
RN - 488-81-3 (Ribitol)
RN - EC 3.2.2.- (N-Glycosyl Hydrolases)
SB - IM